Mmp17^tm1Ski
Targeted Allele Detail

Summary

• Symbol: Mmp17^tm1Ski
• Name: matrix metallopeptidase 17; targeted mutation 1, Motoharu Seiki
• MGI ID: MGI:3777020
• Synonyms: Mt4-mmp^-, Mt4-mmp^LacZ
• Gene: Mmp17 Location: Chr5:129661233-129688163 bp, + strand Genetic Position: Chr5, 68.18 cM
• Alliance: Mmp17^tm1Ski page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:132553
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A lacZ cassette with a nuclear localization sequence and a PGK-gpt/neo cassette were inserted after the translation initiation site in the first exon and replaced part of the first exon through the first intron. The absence of endogenous transcript expression and the presence of a lacZ transcript was confirmed by RT-PCR on brain extracts. This is a null allele. (J:132553)

Expression

In Mice Carrying this Mutation:	104224 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mmp17 Mutation: 34 strains or lines available

References

• Original: J:132553 Rikimaru A, et al., Establishment of an MT4-MMP-deficient mouse strain representing an efficient tracking system for MT4-MMP/MMP-17 expression in vivo using beta-galactosidase. Genes Cells. 2007 Sep;12(9):1091-100
• All: 7 reference(s)