Fkbp8^tm1Kei
Targeted Allele Detail

Summary

• Symbol: Fkbp8^tm1Kei
• Name: FK506 binding protein 8; targeted mutation 1, Keiichi I Nakayama
• MGI ID: MGI:3777160
• Synonyms: Fkbp38^-
• Gene: Fkbp8 Location: Chr8:70980374-70987978 bp, + strand Genetic Position: Chr8, 34.15 cM, cytoband C1
• Alliance: Fkbp8^tm1Kei page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:132541
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The 5.2-kb fragment extending from exon 3 through exon 7 was replaced with a PGK-neo selection cassette. The resulting allele lacks the first ATG codon as well as sequences encoding the FKBP domain and most of the three tetratricopeptide repeat domains. No translation products were detected by immunoblot analysis or by immunofluorescence anyalysis of mouse embryonic fibroblasts. (J:132961)

Disease models

Expression

In Structures Affected by this Mutation:

18 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Fkbp8 Mutation: 22 strains or lines available

References

• Original: J:132541 Nakagawa T, et al., Anchoring of the 26S proteasome to the organellar membrane by FKBP38. Genes Cells. 2007 Jun;12(6):709-19
• All: 3 reference(s)