mt-Co1^m1Jiha
Spontaneous Allele Detail

Summary

• Symbol: mt-Co1^m1Jiha
• Name: mitochondrially encoded cytochrome c oxidase I; mutation 1, Jun-Ichi Hayashi
• MGI ID: MGI:3777237
• Synonyms: B82COI^M, COI^V421A
• Gene: mt-Co1 Location: ChrMT:5328-6872 bp, + strand Genetic Position: ChrMT, Syntenic
• Alliance: mt-Co1^m1Jiha page

Mutation origin

• Strain of Origin: M. m. domesticus

Mutation description

• Allele Type: Spontaneous
• Mutation: Single point mutation
• Mutation details: One B82 mouse cell line deficient for respiration and unable to survive in HAT media contained a spontaneous transition of T-to-C at position 6589 that resulted in an amino acid substitution of valine with alanine at position 421 (p.V421A). (J:132960)

Expression

In Structures Affected by this Mutation:

8 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying mt-Co1^m1Jiha

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any mt-Co1 Mutation: 0 strains or lines available

References

• Original: J:132960 Kasahara A, et al., Generation of trans-mitochondrial mice carrying homoplasmic mtDNAs with a missense mutation in a structural gene using ES cells. Hum Mol Genet. 2006 Mar 15;15(6):871-81
• All: 7 reference(s)