Runx1^tm1Itan
Targeted Allele Detail

Summary

• Symbol: Runx1^tm1Itan
• Name: runt related transcription factor 1; targeted mutation 1, Ichiro Taniuchi
• MGI ID: MGI:3777250
• Synonyms: Runx1^PM12A, Runx1^S249/266A
• Gene: Runx1 Location: Chr16:92398354-92622962 bp, - strand Genetic Position: Chr16, 53.7 cM
• Alliance: Runx1^tm1Itan page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:132661
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Hypomorph)
• Mutation: Nucleotide substitutions
• Mutation details: An exon carrying a nucleotide substitution that resulted in an amino acid substitution of serine to alanine at position 249 and 266 (S249A, S266A) and a floxed neo cassette were knocked into the open reading frame. The neo cassette was removed by transient cre expression. (J:132661)

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)
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hm1	Runx1^tm1Itan/Runx1^tm1Itan	involves: 129P2/OlaHsd

Phenotypes:

Affected Systems	hm1
show or hide all annotated terms
hematopoietic system	N
hematopoietic system phenotype	N
immune system	N
immune system phenotype	N

View phenotypes and curated references for all genotypes (concatenated display).

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Runx1 Mutation: 34 strains or lines available

References

• Original: J:132661 Tachibana M, et al., Phosphorylation of Runx1 at Ser249, Ser266, and Ser276 is dispensable for bone marrow hematopoiesis and thymocyte differentiation. Biochem Biophys Res Commun. 2008 Apr 11;368(3):536-42
• All: 1 reference(s)