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Runx1tm2Itan
Targeted Allele Detail
Summary
Symbol: Runx1tm2Itan
Name: runt related transcription factor 1; targeted mutation 2, Ichiro Taniuchi
MGI ID: MGI:3777251
Synonyms: Runx1PM13A, Runx1S249/276A
Gene: Runx1  Location: Chr16:92398354-92622962 bp, - strand  Genetic Position: Chr16, 53.7 cM
Alliance: Runx1tm2Itan page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:132661
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Hypomorph)
Mutation:    Nucleotide substitutions
 
Mutation detailsAn exoncarrying a nucleotide substitution that resulted in an amino acid substitution of serine to alanine at position 249 and 276 (S249A, S276A) and a floxed neo cassette were knocked into the open reading frame. The neo cassette was removed by transient cre expression. (J:132661)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Runx1 Mutation:  34 strains or lines available
References
Original:  J:132661 Tachibana M, et al., Phosphorylation of Runx1 at Ser249, Ser266, and Ser276 is dispensable for bone marrow hematopoiesis and thymocyte differentiation. Biochem Biophys Res Commun. 2008 Apr 11;368(3):536-42
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/22/2024
MGI 6.24
The Jackson Laboratory