About   Help   FAQ
Runx1tm2Itan
Targeted Allele Detail
Summary
Symbol: Runx1tm2Itan
Name: runt related transcription factor 1; targeted mutation 2, Ichiro Taniuchi
MGI ID: MGI:3777251
Synonyms: Runx1PM13A, Runx1S249/276A
Gene: Runx1  Location: Chr16:92398354-92622962 bp, - strand  Genetic Position: Chr16, 53.7 cM
Alliance: Runx1tm2Itan page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:132661
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Hypomorph)
Mutation:    Nucleotide substitutions
 
Mutation detailsAn exoncarrying a nucleotide substitution that resulted in an amino acid substitution of serine to alanine at position 249 and 276 (S249A, S276A) and a floxed neo cassette were knocked into the open reading frame. The neo cassette was removed by transient cre expression. (J:132661)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Runx1 Mutation:  34 strains or lines available
References
Original:  J:132661 Tachibana M, et al., Phosphorylation of Runx1 at Ser249, Ser266, and Ser276 is dispensable for bone marrow hematopoiesis and thymocyte differentiation. Biochem Biophys Res Commun. 2008 Apr 11;368(3):536-42
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
11/12/2024
MGI 6.24
The Jackson Laboratory