Runx1tm2Itan
Targeted Allele Detail
|
Symbol: |
Runx1tm2Itan |
Name: |
runt related transcription factor 1; targeted mutation 2, Ichiro Taniuchi |
MGI ID: |
MGI:3777251 |
Synonyms: |
Runx1PM13A, Runx1S249/276A |
Gene: |
Runx1 Location: Chr16:92398354-92622962 bp, - strand Genetic Position: Chr16, 53.7 cM
|
Alliance: |
Runx1tm2Itan page
|
|
Germline Transmission: |
Earliest citation of germline transmission:
J:132661
|
Parent Cell Line: |
E14 (ES Cell)
|
Strain of Origin: |
129P2/OlaHsd
|
|
Allele Type: |
|
Targeted (Hypomorph) |
Mutation: |
|
Nucleotide substitutions
|
|
|
Mutation details: An exoncarrying a nucleotide substitution that resulted in an amino acid substitution of serine to alanine at position 249 and 276 (S249A, S276A) and a floxed neo cassette were knocked into the open reading frame. The neo cassette was removed by transient cre expression.
(J:132661)
|
|
|
View phenotypes and curated references for all genotypes (concatenated display).
|
Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
|
Carrying any Runx1 Mutation: |
34 strains or lines available
|
|
Original: |
J:132661 Tachibana M, et al., Phosphorylation of Runx1 at Ser249, Ser266, and Ser276 is dispensable for bone marrow hematopoiesis and thymocyte differentiation. Biochem Biophys Res Commun. 2008 Apr 11;368(3):536-42 |
All: |
1 reference(s) |
|