Dab1^tm1.1Bwh
Targeted Allele Detail

Summary

• Symbol: Dab1^tm1.1Bwh
• Name: disabled 1; targeted mutation 1.1, Brian W Howell
• MGI ID: MGI:3777253
• Synonyms: Dab1^exKIneo
• Gene: Dab1 Location: Chr4:103476556-104602041 bp, + strand Genetic Position: Chr4, 47.79 cM
• Alliance: Dab1^tm1.1Bwh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:132599
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S4/SvJaeSor

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: The coding region of amino acids 23 through 555 was removed by germ-line, cre-mediated recombination. Authors state that this is a null allele based on the phenotypes generated in homozygous mice. (J:132599)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dab1 Mutation: 79 strains or lines available

References

• Original: J:132599 Pramatarova A, et al., A genetic interaction between the APP and Dab1 genes influences brain development. Mol Cell Neurosci. 2008 Jan;37(1):178-86
• All: 1 reference(s)