Traf3tm1Rbr
Targeted Allele Detail
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Symbol: |
Traf3tm1Rbr |
Name: |
TNF receptor-associated factor 3; targeted mutation 1, Robert Brink |
MGI ID: |
MGI:3777324 |
Synonyms: |
Traf3lox |
Gene: |
Traf3 Location: Chr12:111132804-111233587 bp, + strand Genetic Position: Chr12, 60.94 cM, cytoband F
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Alliance: |
Traf3tm1Rbr page
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Germline Transmission: |
Earliest citation of germline transmission:
J:132877
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Parent Cell Line: |
Bruce 4 (ES Cell)
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Strain of Origin: |
B6.Cg-Thy1a
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Allele Type: |
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Targeted (Conditional ready, No functional change) |
Mutation: |
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Insertion
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Mutation details: LoxP sites were inserted around exon 4 of the gene locus and a FRT-flanked neomycin resistance cassette was placed further downstream in intron 4. Chimeric mice were mated with Flp expressing transgenic mice to remove the neomycin cassette. Gene expression was unaffected as determined by immunoblot analysis of lymphoid tissue from homozygotes. Crossing this strain with a strain expressing Cre will lead to deletion of exon 4 and cause a frameshift mutation in the gene locus.
(J:132877)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Traf3 Mutation: |
42 strains or lines available
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Original: |
J:132877 Gardam S, et al., TRAF2 and TRAF3 signal adapters act cooperatively to control the maturation and survival signals delivered to B cells by the BAFF receptor. Immunity. 2008 Mar;28(3):391-401 |
All: |
12 reference(s) |
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