Pla2g6^tm1Tsu
Targeted Allele Detail

Summary

• Symbol: Pla2g6^tm1Tsu
• Name: phospholipase A2, group VI; targeted mutation 1, Yoshihide Tsujimoto
• MGI ID: MGI:3777373
• Synonyms: iPLA2beta^-
• Gene: Pla2g6 Location: Chr15:79170428-79212590 bp, - strand Genetic Position: Chr15, 37.7 cM
• Alliance: Pla2g6^tm1Tsu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:132853
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 9 was replaced with a neomycin resistance cassette. Immunoblot of testicular lysates indicated no protein expression of the targeted locus occurred in homozygotes. (J:132853)

Disease models

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pla2g6 Mutation: 66 strains or lines available

References

• Original: J:132853 Shinzawa K, et al., Neuroaxonal dystrophy caused by group VIA phospholipase A2 deficiency in mice: a model of human neurodegenerative disease. J Neurosci. 2008 Feb 27;28(9):2212-20
• All: 7 reference(s)