Mycbp2^mgln
Chemically induced Allele Detail

Summary

• Symbol: Mycbp2^mgln
• Name: MYC binding protein 2, E3 ubiquitin protein ligase; Magellan
• MGI ID: MGI:3777464
• Synonyms: Phr1^Mag
• Gene: Mycbp2 Location: Chr14:103350847-103584250 bp, - strand Genetic Position: Chr14, 51.79 cM
• Alliance: Mycbp2^mgln page

Mutation origin

• Strain of Origin: (BALB/c x C57BL/6)F1 X DBA/2J

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: ENU mutagenesis induced an G to T transition in exon 63 that resulted in a premature termination codon. The presence of a truncated protein lacking the C-terminal RING finger domain was confirmed by western blot analysis. (J:132726)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mycbp2 Mutation: 224 strains or lines available

Notes

ENU exposed DBA/2J males were mated with (BALB/c x C57BL/6)F1 females carrying the Tg(Isl1-EGFP*)1Slp reporter.

References

• Original: J:132726 Lewcock JW, et al., The ubiquitin ligase Phr1 regulates axon outgrowth through modulation of microtubule dynamics. Neuron. 2007 Nov 21;56(4):604-20
• All: 3 reference(s)