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Rettm2(RET)Heno
Targeted Allele Detail
Summary
Symbol: Rettm2(RET)Heno
Name: ret proto-oncogene; targeted mutation 2, Hideki Enomoto
MGI ID: MGI:3777555
Synonyms: Retf(CFP), RetfCFP, Retflox
Gene: Ret  Location: Chr6:118128706-118174679 bp, - strand  Genetic Position: Chr6, 55.86 cM, cytoband E3-F1
Alliance: Rettm2(RET)Heno page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:132854
Parent Cell Line:  RW-4 (ES Cell)
Strain of Origin:  129X1/SvJ
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA floxed human RET cDNA with an SV40 intron and poly-adenyation site followed by CFP with a poly-adenylation site and an frt-flanked neo cassette were inserted into exon 1 removing 39 base pairs including the start methionine codon and codons for the first 6 amino acids of the signal peptide. Germ-line, flp-mediated recombination was used to remove the neo cassette and leave a floxed RET and a CFP cassette. (J:132854)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 2 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ret Mutation:  54 strains or lines available
References
Original:  J:132854 Gould TW, et al., The neurotrophic effects of glial cell line-derived neurotrophic factor on spinal motoneurons are restricted to fusimotor subtypes. J Neurosci. 2008 Feb 27;28(9):2131-46
All:  18 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/22/2024
MGI 6.24
The Jackson Laboratory