Rettm2(RET)Heno
Targeted Allele Detail
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Symbol: |
Rettm2(RET)Heno |
Name: |
ret proto-oncogene; targeted mutation 2, Hideki Enomoto |
MGI ID: |
MGI:3777555 |
Synonyms: |
Retf(CFP), RetfCFP, Retflox |
Gene: |
Ret Location: Chr6:118128706-118174679 bp, - strand Genetic Position: Chr6, 55.86 cM, cytoband E3-F1
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Alliance: |
Rettm2(RET)Heno page
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Germline Transmission: |
Earliest citation of germline transmission:
J:132854
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Parent Cell Line: |
RW-4 (ES Cell)
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Strain of Origin: |
129X1/SvJ
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Allele Type: |
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Targeted (Conditional ready, No functional change) |
Mutations: |
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Insertion, Intragenic deletion
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Mutation details: A floxed human RET cDNA with an SV40 intron and poly-adenyation site followed by CFP with a poly-adenylation site and an frt-flanked neo cassette were inserted into exon 1 removing 39 base pairs including the start methionine codon and codons for the first 6 amino acids of the signal peptide. Germ-line, flp-mediated recombination was used to remove the neo cassette and leave a floxed RET and a CFP cassette.
(J:132854)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Ret Mutation: |
54 strains or lines available
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Original: |
J:132854 Gould TW, et al., The neurotrophic effects of glial cell line-derived neurotrophic factor on spinal motoneurons are restricted to fusimotor subtypes. J Neurosci. 2008 Feb 27;28(9):2131-46 |
All: |
18 reference(s) |
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