Sez6^tm1.1Sest
Targeted Allele Detail

Summary

• Symbol: Sez6^tm1.1Sest
• Name: seizure related gene 6; targeted mutation 1.1, Seong-Seng Tan
• MGI ID: MGI:3777582
• Gene: Sez6 Location: Chr11:77821626-77869874 bp, + strand Genetic Position: Chr11, 46.74 cM
• Alliance: Sez6^tm1.1Sest page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:132725
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A floxed neo cassette was inserted downstream of exon 1 and an additional loxP site was inserted upstream of exon 1. Transient cre expression in ES cells was used to remove exon 1. The absence of protein expression was confirmed by immunohistochemistry and western blot analysis on brain extracts. (J:132725)

Expression

In Mice Carrying this Mutation:	8 assay results
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sez6 Mutation: 72 strains or lines available

References

• Original: J:132725 Gunnersen JM, et al., Sez-6 proteins affect dendritic arborization patterns and excitability of cortical pyramidal neurons. Neuron. 2007 Nov 21;56(4):621-39
• All: 2 reference(s)