Npr3^m1Btlr
Chemically induced Allele Detail

Summary

• Symbol: Npr3^m1Btlr
• Name: natriuretic peptide receptor 3; mutation 1, Bruce Beutler
• MGI ID: MGI:3777586
• Synonyms: eel
• Gene: Npr3 Location: Chr15:11839982-11907287 bp, - strand Genetic Position: Chr15, 5.83 cM
• Alliance: Npr3^m1Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: The mutation is an A-to-T transversion at nucleotide position 1185 (Genbank Accession NM_008728) that results in replacement of isoleucine by phenylalanine at amino acid postion 384 of the protein (p.I384F), in the membrane-proximal region of the extracellular domain. (J:132964)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Npr3 Mutation: 50 strains or lines available

References

• Original: J:132964 Du X, et al., Eel, an ENU-induced mutation of Npr3 associated with spinal abnormalities. MGI Direct Data Submission. 2008
• All: 1 reference(s)