Rap1a^tm1Morz
Targeted Allele Detail

Summary

• Symbol: Rap1a^tm1Morz
• Name: RAS-related protein 1a; targeted mutation 1, Alexei Morozov
• MGI ID: MGI:3777591
• Synonyms: Rap1A^floxed
• Gene: Rap1a Location: Chr3:105634583-105708652 bp, - strand Genetic Position: Chr3, 46.45 cM
• Alliance: Rap1a^tm1Morz page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:132855
• Parent Cell Line: MM13 (ES Cell)
• Strain of Origin: 129S/SvEv

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 2 and a loxP-flanked neomycin selection cassette was inserted downstream of exon 3. Transient expression of cre recombinase removed the neomycin cassette, leaving exons 2 and 3 flanked by loxP sites. Correct targeting was confirmed through Southern blots. (J:132855)

Expression

In Mice Carrying this Mutation:

123 assay results

Tumor Data

List all tumor models in MMHCdb carrying Rap1a^tm1Morz

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Rap1a Mutation: 25 strains or lines available

References

• Original: J:132855 Pan BX, et al., Enhanced cortico-amygdala efficacy and suppressed fear in absence of Rap1. J Neurosci. 2008 Feb 27;28(9):2089-98
• All: 30 reference(s)