Nanos3^tm2(cre)Ysa
Targeted Allele Detail

Summary

• Symbol: Nanos3^tm2(cre)Ysa
• Name: nanos C2HC-type zinc finger 3; targeted mutation 2, Yumiko Saga
• MGI ID: MGI:3777592
• Synonyms: Nanos3-Cre
• Gene: Nanos3 Location: Chr8:84900359-84911396 bp, - strand Genetic Position: Chr8, 40.45 cM
• Alliance: Nanos3^tm2(cre)Ysa page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:132711
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Recombinase)
• Mutation: Insertion
• Nanos3^tm2(cre)Ysa expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Nanos3 (MGI:2675387)

• Mutation details: The cre recombinase coding sequence and SV40 polyadenylation signal followed by an frt-flanked PGK-neo selection cassette (in the opposite orientation) was inserted into exon1 by homologous recombination of the Nanos3 gene in TT2 ES cells. Expression is detected at E7.75 in germ cells during the migration stage and after entry into the gonad. (J:136687)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Nanos3 (mouse) Summary of all recombinase alleles driven by Nanos3. Alliance mouse Nanos3 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Nanos3 Mutation: 28 strains or lines available

References

• Original: J:132711 Suzuki A, et al., Nanos2 suppresses meiosis and promotes male germ cell differentiation. Genes Dev. 2008 Feb 15;22(4):430-5
• All: 8 reference(s)