Rap1b^tm1Morz
Targeted Allele Detail

Summary

• Symbol: Rap1b^tm1Morz
• Name: RAS related protein 1b; targeted mutation 1, Alexei Morozov
• MGI ID: MGI:3777593
• Synonyms: Rap1B^floxed
• Gene: Rap1b Location: Chr10:117650502-117681879 bp, - strand Genetic Position: Chr10, 66.32 cM, cytoband D2
• Alliance: Rap1b^tm1Morz page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:132855
• Parent Cell Line: MM13 (ES Cell)
• Strain of Origin: 129S/SvEv

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP-flanked neomycin selection cassette was inserted upstream of exon 1 with an additional loxP site inserted downstream of the exon. Transient expression of cre recombinase removed the neomycin selection cassette leaving exon 1 flanked by loxP sites. Correct targeted was confirmed through Southern blotting. (J:132855)

Expression

In Mice Carrying this Mutation:

123 assay results

Tumor Data

List all tumor models in MMHCdb carrying Rap1b^tm1Morz

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Rap1b Mutation: 32 strains or lines available

References

• Original: J:132855 Pan BX, et al., Enhanced cortico-amygdala efficacy and suppressed fear in absence of Rap1. J Neurosci. 2008 Feb 27;28(9):2089-98
• All: 31 reference(s)