Chrng^tm1Vwi
Targeted Allele Detail

Summary

• Symbol: Chrng^tm1Vwi
• Name: cholinergic receptor, nicotinic, gamma polypeptide; targeted mutation 1, Veit Witzemann
• MGI ID: MGI:3777606
• Synonyms: AChR^gamma-GFP
• Gene: Chrng Location: Chr1:87133533-87139365 bp, + strand Genetic Position: Chr1, 44.07 cM
• Alliance: Chrng^tm1Vwi page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:132703
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: Exons 4 through 12 were replaced with a genomic segment containing exons 1 through 4 with a GFP cassette inserted into intron 3 and a neo cassette inserted into exon 4. Expression of the GFP cassette was confirmed by fluorescence microscopy. Transcriptional efficiency of the allele is reduced compared to wild-type. (J:132703)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Chrng Mutation: 31 strains or lines available

References

• Original: J:132703 Yampolsky P, et al., AChR channel conversion and AChR-adjusted neuronal survival during embryonic development. Mol Cell Neurosci. 2008 Mar;37(3):634-45
• All: 2 reference(s)