Nfkbid^tm1Clay
Targeted Allele Detail

Summary

• Symbol: Nfkbid^tm1Clay
• Name: nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, delta; targeted mutation 1, Linda K Clayton
• MGI ID: MGI:3777661
• Synonyms: IkappaBNS^-
• Gene: Nfkbid Location: Chr7:30121157-30128171 bp, + strand Genetic Position: Chr7, 17.52 cM
• Alliance: Nfkbid^tm1Clay page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:132071
• Parent Cell Line: W4 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 4.8 kb region of the gene containing exons 1 through 5 and most of exon 6 was replaced by a neomycin resistance cassette. No gene expression is detected in microarray analysis of homozygote T cells. (J:132071)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Nfkbid Mutation: 22 strains or lines available

References

• Original: J:132071 Touma M, et al., Functional role for I kappa BNS in T cell cytokine regulation as revealed by targeted gene disruption. J Immunol. 2007 Aug 1;179(3):1681-92
• All: 9 reference(s)