Tg(TcraN15,TcrbN15)L2Elre
Transgene Detail

Summary

• Symbol: Tg(TcraN15,TcrbN15)L2Elre
• Name: transgene insertion L2, Ellis L Reinherz
• MGI ID: MGI:3777745
• Synonyms: N15tg
• Transgene: Tg(TcraN15,TcrbN15)L2Elre Location: unknown
• Alliance: Tg(TcraN15,TcrbN15)L2Elre page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(TcraN15,TcrbN15)L2Elre expresses 2 genes
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Tcra (MGI:98553)
  mouse	Tcrb (MGI:98578)

• Mutation details: Fertilized eggs homozygous for the null Rag2^tm1Fwa allele were co-injected with transgenes encoding the rearranged Tcra and Tcrb genes isolated from the CD8 positive T cell clone N15. These transgenes encode a T cell receptor specific for the vesicular stomatitis virus nuclear octapeptide antigen (VSV8) presented by the MHC-I variant K^b. Expression of the transgenes by thymocytes was confirmed by flow cytometry analysis using an antibody specific for the transgenic TCR. (J:133112)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:133112 Ghendler Y, et al., Double-positive T cell receptor(high) thymocytes are resistant to peptide/major histocompatibility complex ligand-induced negative selection. Eur J Immunol. 1997 Sep;27(9):2279-89
• All: 7 reference(s)