Atp7a^Mo-Btlr
Chemically induced Allele Detail

Summary

• Symbol: Atp7a^Mo-Btlr
• Name: ATPase, copper transporting, alpha polypeptide; mottled Bruce Beutler
• MGI ID: MGI:3777914
• Synonyms: Atp7a^Tigrou-like, tigrou-like
• Gene: Atp7a Location: ChrX:105070882-105168532 bp, + strand Genetic Position: ChrX, 47.36 cM
• Alliance: Atp7a^Mo-Btlr page

Coat color phenotypes of mutants carrying the Atp7a^Mo-Btlr, Atp7a^Mo-2Btlr, or Atp7a^Mo-3Btlr allele

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: The tigrou-like mutation corresponds to a C-to-T transition at nucleotide position 3073, in exon 15 of 23 total exons, that results in replacement of alanine by valine at amino acid 999 of the protein. This is in the highly conserved sixth transmembrane domain that participates in formation of the cation channel. (J:133115, J:188598)
• Inheritance: Semidominant

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Atp7a Mutation: 69 strains or lines available

References

• Original: J:133115 Smart NG, et al., Tigrou-like is an allele of the copper transporter Atp7a and causes male lethality. MGI Direct Data Submission. 2008
• All: 2 reference(s)