Myo5a^d-Btlr
Chemically induced Allele Detail

Summary

• Symbol: Myo5a^d-Btlr
• Name: myosin VA; dilute Bruce Beutler
• MGI ID: MGI:3777919
• Synonyms: new gray
• Gene: Myo5a Location: Chr9:74978297-75130970 bp, + strand Genetic Position: Chr9, 42.26 cM
• Alliance: Myo5a^d-Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Nucleotide substitutions
• Mutation details: The mutation is a dinucleotide transition in adjacent nucleotides (GC to AT) at positions 1972 and 1973 (Genbank Accession NM_010864), in exon 13 of 41 exons, that changes two codons such that two amino acids in the head region of the protein are altered: methionine at amino acid position 515 is replaced by isoleucine (p.M515I) and proline at position 516 by serine (p.P516S). (J:133117)
• Inheritance: Recessive

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Myo5a Mutation: 265 strains or lines available

References

• Original: J:133117 Eidenschenk C, et al., New gray, an ENU-induced Myo5a mutation conferring dilute coat color and black eyes. MGI Direct Data Submission. 2008
• All: 1 reference(s)