Pnp^e
Chemically induced Allele Detail

Summary

• Symbol: Pnp^e
• Name: purine-nucleoside phosphorylase; NP-1E
• MGI ID: MGI:3777967
• Synonyms: Np-1^e
• Gene: Pnp Location: Chr14:51181760-51190869 bp, + strand Genetic Position: Chr14, 26.31 cM, cytoband B-C1
• Alliance: Pnp^e page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: This allele was identified in the progeny of a cross between ENU mutagenized C57BL/6J males and C3H/HeHa females. A T to A transversion occurred at nuleotide 260 causing an M87K amino acid substitution in the protein. (J:491, J:23354, J:39328)

Disease models

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pnp Mutation: 29 strains or lines available

References

• Original: J:23354 Mably ER, et al., Genetic deficiency of purine nucleoside phosphorylase in the mouse. Characterization of partially and severely enzyme deficient mutants. Genome. 1989 Dec;32(6):1026-32
• All: 6 reference(s)