Txnip^tm1.1Road
Targeted Allele Detail

Summary

• Symbol: Txnip^tm1.1Road
• Name: thioredoxin interacting protein; targeted mutation 1.1, Roger Davis
• MGI ID: MGI:3778277
• Gene: Txnip Location: Chr3:96465273-96469173 bp, + strand Genetic Position: Chr3, 41.93 cM, cytoband F2.2
• Alliance: Txnip^tm1.1Road page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:132756
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Germ-line, cre-mediated recombination was used to remove exons 2 through 8. The absence of transcript was confirmed by quantitative RT-PCR. (J:132756)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Txnip Mutation: 49 strains or lines available

References

• Original: J:132756 Hui ST, et al., Txnip balances metabolic and growth signaling via PTEN disulfide reduction. Proc Natl Acad Sci U S A. 2008 Mar 11;105(10):3921-6
• All: 10 reference(s)