Tg(DRD1-ctxA)7Burt
Transgene Detail

Summary

• Symbol: Tg(DRD1-ctxA)7Burt
• Name: transgene insertion 7, Frank H Burton
• MGI ID: MGI:3778286
• Synonyms: D1CT-7, Ticcy
• Transgene: Tg(DRD1-ctxA)7Burt Location: unknown
• Alliance: Tg(DRD1-ctxA)7Burt page

Transgene origin

• Strain of Origin: BALB/c x C57BL/6

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: The transgenic construct contains the cholera toxin intracellular enzymatic subunit A1 gene (ctxA) under the control of the 6.5 kb promoter of the human dopamine receptor D1, DRD1. Founder line 7 subsequently was established. Another female founder, 11, was produced but because this founder exhibited severe hyperreactivity in response to novel stimuli or introduction of potential mates, breeding this animal and estabilshing this line was precluded. (J:55492)

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:55492 Campbell KM, et al., OCD-Like behaviors caused by a neuropotentiating transgene targeted to cortical and limbic D1+ neurons. J Neurosci. 1999 Jun 15;19(12):5044-53
• All: 8 reference(s)