Cdh13^tm1Brns
Targeted Allele Detail

Summary

• Symbol: Cdh13^tm1Brns
• Name: cadherin 13; targeted mutation 1, Barbara Ranscht
• MGI ID: MGI:3778287
• Synonyms: T-cadherin^-, Tcad KO
• Gene: Cdh13 Location: Chr8:119010472-120051660 bp, + strand Genetic Position: Chr8, 65.97 cM
• Alliance: Cdh13^tm1Brns page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:132759
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A neo cassette was inserted into exon 5 that encodes the extracellular domain. The absence of protein product was confirmed by western blot analysis on fat pad extracts. (J:132759)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Cdh13 Mutation: 32 strains or lines available

References

• Original: J:132759 Hebbard LW, et al., T-cadherin supports angiogenesis and adiponectin association with the vasculature in a mouse mammary tumor model. Cancer Res. 2008 Mar 1;68(5):1407-16
• All: 13 reference(s)