Sp6^tm1Ibmm
Targeted Allele Detail

Summary

• Symbol: Sp6^tm1Ibmm
• Name: trans-acting transcription factor 6; targeted mutation 1, Claude Szpirer
• MGI ID: MGI:3778292
• Gene: Sp6 Location: Chr11:96904395-96915565 bp, + strand Genetic Position: Chr11, 60.51 cM
• Alliance: Sp6^tm1Ibmm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:132771
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: An frt-flanked neo cassette with a 3' loxP site was inserted into intron 1 and an additional loxP site was inserted into the 3' untranslated region in exon 2. Germ-line, flp-mediated recombiation was used to remove the neo cassette leaving the open reading frame floxed. (J:132771)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Sp6 Mutation: 18 strains or lines available

References

• Original: J:132771 Hertveldt V, et al., The development of several organs and appendages is impaired in mice lacking Sp6. Dev Dyn. 2008 Apr;237(4):883-92
• All: 2 reference(s)