Edaradd^cr-2Btlr
Chemically induced Allele Detail

Summary

• Symbol: Edaradd^cr-2Btlr
• Name: EDAR associated via death domain; crinkled 2 Beutler
• MGI ID: MGI:3778293
• Synonyms: Edaradd^m2Btlr, gizmo
• Gene: Edaradd Location: Chr13:12487513-12535319 bp, - strand Genetic Position: Chr13, 4.77 cM
• Alliance: Edaradd^cr-2Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Undefined
• Mutation details: The mutant transcript was analyzed by RT-PCR and found to be lacking the 59-nucleotide exon 4 (of 6 total exons). The nature of the mutation at the genomic DNA level has not been determined. Deletion of exon 4 is predicted to shift the reading frame after amino acid 43, adding 4 aberrant amino acids and creating a premature stop codon that would truncate the protein after amino acid 47. (J:133273)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Edaradd Mutation: 16 strains or lines available

References

• Original: J:133273 Du X, et al., Gizmo is an allele of Edaradd, which functions in the EDAR signaling pathway. MGI Direct Data Submission. 2008
• All: 1 reference(s)