Sp6^tm1.1Ibmm
Targeted Allele Detail

Summary

• Symbol: Sp6^tm1.1Ibmm
• Name: trans-acting transcription factor 6; targeted mutation 1.1, Claude Szpirer
• MGI ID: MGI:3778294
• Gene: Sp6 Location: Chr11:96904395-96915565 bp, + strand Genetic Position: Chr11, 60.51 cM
• Alliance: Sp6^tm1.1Ibmm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:132771
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Germ-line, cre-mediated recombination was used to remove the open reading frame. The absence of transcript was confirmed by RT-PCR on head and skin extracts. (J:132771)

Expression

In Structures Affected by this Mutation:

19 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Sp6 Mutation: 18 strains or lines available

References

• Original: J:132771 Hertveldt V, et al., The development of several organs and appendages is impaired in mice lacking Sp6. Dev Dyn. 2008 Apr;237(4):883-92
• All: 1 reference(s)