Slc51a^tm1Pda
Targeted Allele Detail

Summary

• Symbol: Slc51a^tm1Pda
• Name: solute carrier family 51, alpha subunit; targeted mutation 1, Paul A Dawson
• MGI ID: MGI:3778302
• Gene: Slc51a Location: Chr16:32294396-32306697 bp, - strand Genetic Position: Chr16, 22.7 cM
• Alliance: Slc51a^tm1Pda page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:132778
• Parent Cell Line: SM1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 1 and 2 were replaced with a neo cassette. The absence of protein product was confirmed by western blot analysis on ileal extracts. (J:132778)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Slc51a Mutation: 22 strains or lines available

References

• Original: J:132778 Rao A, et al., The organic solute transporter alpha-beta, Ostalpha-Ostbeta, is essential for intestinal bile acid transport and homeostasis. Proc Natl Acad Sci U S A. 2008 Mar 11;105(10):3891-6
• All: 5 reference(s)