Kit^W-Btlr
Chemically induced Allele Detail

Summary

• Symbol: Kit^W-Btlr
• Name: KIT proto-oncogene receptor tyrosine kinase; viable dominant spotting Bruce Beutler
• MGI ID: MGI:3778370
• Synonyms: casper, Kit^m1Btlr
• Gene: Kit Location: Chr5:75735647-75817382 bp, + strand Genetic Position: Chr5, 39.55 cM
• Alliance: Kit^W-Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: The casper mutation corresponds to an A-to-G transition at nucleotide position 2055, in exon 14 of 21 total exons, resulting in replacement of aspartic acid by glycine at amino acid position 636 (D676G). (J:133270)
• Inheritance: Semidominant

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kit Mutation: 182 strains or lines available

References

• Original: J:133270 Du X, et al., Casper is an allele of Kit, and displays pigmentation defects. MGI Direct Data Submission. 2008
• All: 1 reference(s)