Mstn^tm2Sjl
Targeted Allele Detail

Summary

• Symbol: Mstn^tm2Sjl
• Name: myostatin; targeted mutation 2, Se-Jin Lee
• MGI ID: MGI:3778375
• Synonyms: Mstn^D76A
• Gene: Mstn Location: Chr1:53100799-53107238 bp, + strand Genetic Position: Chr1, 26.99 cM
• Alliance: Mstn^tm2Sjl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:132807
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: The first coding region was replaced with one that contained a nucleotide substitution resulting in an amino acid substitution of alanine for aspartic acid at position 76. A floxed neo cassette was inserted upstream of the C-terminusd encoding exon and removed by germ-line, cre-mediated recombination. (J:132807)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mstn Mutation: 34 strains or lines available

References

• Original: J:132807 Lee SJ, Genetic analysis of the role of proteolysis in the activation of latent myostatin. PLoS One. 2008;3(2):e1628
• All: 1 reference(s)