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Gata1tm10Sho
Targeted Allele Detail
Summary
Symbol: Gata1tm10Sho
Name: GATA binding protein 1; targeted mutation 10, Stuart H Orkin
MGI ID: MGI:3778536
Synonyms: Gata13SA
Gene: Gata1  Location: ChrX:7825504-7842844 bp, - strand  Genetic Position: ChrX, 3.59 cM, cytoband A2
Alliance: Gata1tm10Sho page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:132560
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Not Specified)
Mutations:    Insertion, Nucleotide substitutions
 
Mutation detailsA floxed neo cassette was inserted downstream of exon 4 and exon 2, 3 and 6 were replaced with the corresponding exons containing nucleotide substitutions that resulted in amino acid substitutions of alanine for serine at positions 72, 142 and 310 (S72A, S142A and S310A). The neo cassette was removed by germ-line, cre-mediated recombination. (J:132560)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gata1 Mutation:  45 strains or lines available
References
Original:  J:132560 Rooke HM, et al., Phosphorylation of Gata1 at serine residues 72, 142, and 310 is not essential for hematopoiesis in vivo. Blood. 2006 May 1;107(9):3527-30
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory