Bmf^tm1.1Ast
Targeted Allele Detail

Summary

• Symbol: Bmf^tm1.1Ast
• Name: BCL2 modifying factor; targeted mutation 1.1, Andreas Strasser
• MGI ID: MGI:3778610
• Synonyms: Bmf^tm1.1Anvi
• Gene: Bmf Location: Chr2:118359238-118380168 bp, - strand Genetic Position: Chr2, 59.4 cM, cytoband E5
• Alliance: Bmf^tm1.1Ast page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:133084
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Exons 3 and 4 were deleted by germ-line, cre-mediated recombination. The absence of protein product was confirmed by western blot analysis of spleen, lymph node and thymus extracts. (J:133084)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Bmf^tm1.1Ast

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Bmf Mutation: 21 strains or lines available

References

• Original: J:133084 Labi V, et al., Loss of the BH3-only protein Bmf impairs B cell homeostasis and accelerates gamma irradiation-induced thymic lymphoma development. J Exp Med. 2008 Mar 17;205(3):641-55
• All: 16 reference(s)