Del(6Ephb6-Trpv6)1Mhed
Targeted Allele Detail

Summary

• Symbol: Del(6Ephb6-Trpv6)1Mhed
• Name: deletion, Chr 6, Matthias Hedinger 1
• MGI ID: MGI:3778644
• Synonyms: Del1Mhed, Ephb6/Trpv6^tm1Mhed
• Gene: Del(6Ephb6-Trpv6)1Mhed Location: unknown Genetic Position: Chr6, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:133151
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S/SvEv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intergenic deletion, Intragenic deletion
• Del(6Ephb6-Trpv6)1Mhed involves 2 genes/genome features (Ephb6, Trpv6) View all
• Mutation details: Part of intron 6, exon 7 and exon 8 and part of exon 9 were replaced with a neo cassette. This replaces most of the coding region from the transmembrane domain to the end of the protein. The absence of protein product was confirmed by western blot analysis on intestine extracts. The gene targeting also replaces the last 4 exons of Ephb6 that encode the SAM domain and part of the kinase domain. No molecular evidence is presented as to the effect of this deletion. (J:133151)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Del(6Ephb6-Trpv6)1Mhed Mutation: 0 strains or lines available

References

• Original: J:133151 Bianco SD, et al., Marked disturbance of calcium homeostasis in mice with targeted disruption of the Trpv6 calcium channel gene. J Bone Miner Res. 2007 Feb;22(2):274-85
• All: 8 reference(s)