Affected Systems |
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behavior/neurological
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√
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absent startle reflex
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√
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abnormal motor coordination/balance
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√
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head tilt
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√
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head tossing
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√
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cellular
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√
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√
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√
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abnormal cell physiology
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√
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√
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increased melanoblast apoptosis
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√
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abnormal melanocyte proliferation
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√
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√
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craniofacial
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√
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thick ears
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√
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embryo
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√
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increased melanoblast apoptosis
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√
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abnormal melanoblast morphology
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√
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endocrine/exocrine glands
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√
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abnormal Harderian gland pigmentation
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√
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growth/size/body
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√
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√
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thick ears
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√
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decreased body weight
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√
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√
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hearing/vestibular/ear
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√
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thick ears
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√
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increased or absent threshold for auditory brainstem response
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√
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immune system
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√
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enlarged lymph nodes
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√
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integument
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√
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√
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√
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√
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√
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abnormal coat/hair pigmentation
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√
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dermal-epidermal separation
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√
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abnormal skin pigmentation
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√
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abnormal dermal pigmentation
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√
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√
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abnormal epidermal pigmentation
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√
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√
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√
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reduced foot pad pigmentation
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√
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increased foot pad pigmentation
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√
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abnormal tail pigmentation
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√
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√
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decreased tail pigmentation
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√
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increased tail pigmentation
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√
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√
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decreased skin pigmentation
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√
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limbs/digits/tail
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√
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√
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√
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√
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√
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reduced foot pad pigmentation
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√
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increased foot pad pigmentation
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√
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abnormal tail pigmentation
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√
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√
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decreased tail pigmentation
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√
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increased tail pigmentation
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√
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√
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neoplasm
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√
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increased metastatic potential
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√
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increased intraocular melanoma incidence
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√
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nervous system
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√
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√
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abnormal melanoblast morphology
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√
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abnormal spinal cord meninges morphology
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√
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pigmentation
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N
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√
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√
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√
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√
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√
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√
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√
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pigmentation phenotype
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N
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N
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abnormal melanocyte proliferation
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√
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√
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abnormal coat/hair pigmentation
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√
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abnormal skin pigmentation
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√
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abnormal dermal pigmentation
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√
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√
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abnormal epidermal pigmentation
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√
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√
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√
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abnormal tail pigmentation
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√
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√
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decreased tail pigmentation
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√
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increased tail pigmentation
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√
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√
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abnormal extracutaneous pigmentation
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√
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abnormal Harderian gland pigmentation
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√
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abnormal eye pigmentation
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√
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abnormal choroid pigmentation
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√
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abnormal leptomeninges pigmentation
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√
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abnormal otic pigmentation
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√
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abnormal melanocyte morphology
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√
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abnormal melanocyte number
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√
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√
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decreased melanocyte number
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√
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abnormal melanosome morphology
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√
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ectopic melanocytes
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√
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hyperpigmentation
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√
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increased foot pad pigmentation
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√
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hypopigmentation
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√
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reduced foot pad pigmentation
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√
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decreased skin pigmentation
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√
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vision/eye
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√
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√
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abnormal eye pigmentation
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√
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abnormal anterior eye segment morphology
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√
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exophthalmos
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√
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microphthalmia
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√
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abnormal uvea morphology
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√
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increased intraocular melanoma incidence
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√
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abnormal choroid pigmentation
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√
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