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Tg(Mitf-cre)7114Gsb
Transgene Detail
Summary
Symbol: Tg(Mitf-cre)7114Gsb
Name: transgene insertion 7114, Gregory S Barsh
MGI ID: MGI:3778684
Synonyms: MitfCre
Transgene: Tg(Mitf-cre)7114Gsb  Location: unknown  
Alliance: Tg(Mitf-cre)7114Gsb page
Transgene
origin
Strain of Origin:  (CBA x C57BL/6)F1
Transgene
description
Transgene Type:    Transgenic (Recombinase)
Mutation:    Insertion
 
Tg(Mitf-cre)7114Gsb expression driven by 1 gene
 
Mutation detailsA cre coding region was inserted prior to the protein coding region of Mitf contained within BAC RP23-271N22. 3 lines were created and one line was studied (line 7114). Cre expression under the control of the Mitf promoter was confirmed to be melanocyte-specific. (J:132975)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Mitf (mouse)
Summary of all recombinase alleles driven by Mitf.
 

Phenotypes
Key:
hm homozygous ht heterozygous tg involves transgenes phenotype observed
cn conditional genotype  cx complex: > 1 genome feature ot other: hemizygous, indeterminate,... N normal phenotype
Genotype/
Background:
Phenotypes:
Affected Systems
show or hide all annotated terms
                   
behavior/neurological
absent startle reflex
abnormal motor coordination/balance
head tilt
head tossing
cellular
abnormal cell physiology
increased melanoblast apoptosis
abnormal melanocyte proliferation
craniofacial
thick ears
embryo
increased melanoblast apoptosis
abnormal melanoblast morphology
endocrine/exocrine glands
abnormal Harderian gland pigmentation
growth/size/body
thick ears
decreased body weight
hearing/vestibular/ear
thick ears
increased or absent threshold for auditory brainstem response
immune system
enlarged lymph nodes
integument
abnormal coat/hair pigmentation
dermal-epidermal separation
abnormal skin pigmentation
abnormal dermal pigmentation
abnormal epidermal pigmentation
reduced foot pad pigmentation
increased foot pad pigmentation
abnormal tail pigmentation
decreased tail pigmentation
increased tail pigmentation
decreased skin pigmentation
limbs/digits/tail
reduced foot pad pigmentation
increased foot pad pigmentation
abnormal tail pigmentation
decreased tail pigmentation
increased tail pigmentation
neoplasm
increased metastatic potential
increased intraocular melanoma incidence
nervous system
abnormal melanoblast morphology
abnormal spinal cord meninges morphology
pigmentation
N
pigmentation phenotype
N N
abnormal melanocyte proliferation
abnormal coat/hair pigmentation
abnormal skin pigmentation
abnormal dermal pigmentation
abnormal epidermal pigmentation
abnormal tail pigmentation
decreased tail pigmentation
increased tail pigmentation
abnormal extracutaneous pigmentation
abnormal Harderian gland pigmentation
abnormal eye pigmentation
abnormal choroid pigmentation
abnormal leptomeninges pigmentation
abnormal otic pigmentation
abnormal melanocyte morphology
abnormal melanocyte number
decreased melanocyte number
abnormal melanosome morphology
ectopic melanocytes
hyperpigmentation
increased foot pad pigmentation
hypopigmentation
reduced foot pad pigmentation
decreased skin pigmentation
vision/eye
abnormal eye pigmentation
abnormal anterior eye segment morphology
exophthalmos
microphthalmia
abnormal uvea morphology
increased intraocular melanoma incidence
abnormal choroid pigmentation
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Key:
disease model   expected model not found
Models:
Human Diseases
cn3
IDs
Expression
In Structures Affected by this Mutation: 2 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:132975 Alizadeh A, et al., Melanocyte-lineage expression of Cre recombinase using Mitf regulatory elements. Pigment Cell Melanoma Res. 2008 Feb;21(1):63-9
All:  7 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory