Cyp11a1^tm2Bcc
Targeted Allele Detail

Summary

• Symbol: Cyp11a1^tm2Bcc
• Name: cytochrome P450, family 11, subfamily a, polypeptide 1; targeted mutation 2, Bon-Chu Chung
• MGI ID: MGI:3778793
• Synonyms: Cyp11a1^L
• Gene: Cyp11a1 Location: Chr9:57913694-57934306 bp, + strand Genetic Position: Chr9, 31.63 cM
• Alliance: Cyp11a1^tm2Bcc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:133007
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: The proximal SF-1 binding site in intron 1 was replaced with one in which the genetic sequence was altered from TAGCCTTGA to TAGaaTTGA. A floxed neo cassette with a 3' lox P site was inserted in intron 1 but was removed by germ-line, cre-mediated recombination. Expression of the protein product was reduced 7-fold in the adrenal and testis but was unaffected in the placenta and ovary. (J:133007)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Cyp11a1 Mutation: 42 strains or lines available

References

• Original: J:133007 Shih MC, et al., Mutation of Mouse Cyp11a1 Promoter Caused Tissue-Specific Reduction of Gene Expression and Blunted Stress Response without Affecting Reproduction. Mol Endocrinol. 2008 Apr;22(4):915-23
• All: 1 reference(s)