Vangl1^Gt(XL802)Byg
Gene trapped Allele Detail

Summary

• Symbol: Vangl1^Gt(XL802)Byg
• Name: VANGL planar cell polarity 1; gene trap XL802, BayGenomics
• MGI ID: MGI:3778822
• Synonyms: Vangl1^gt
• Gene: Vangl1 Location: Chr3:102060899-102112009 bp, - strand Genetic Position: Chr3, 44.3 cM
• Alliance: Vangl1^Gt(XL802)Byg page

Vangl1^Gt(XL802)Byg/Vangl1⁺ Vangl2^Lp/Vangl2⁺ and Vangl2^Lp/Vangl2^Lp embryos exhibit aberrant right subclavian artery

Show the 4 phenotype image(s) involving this allele.

Mutation origin

• Mutant Cell Line: XL802
• Germline Transmission: Earliest citation of germline transmission: J:132697
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Gene trapped (Reporter)
• Mutation: Insertion of gene trap vector Vector: pGT0Lxf Vector Type: gene trap
• Mutation details: A pGT0Lxf beta-geo gene-trap vector inserted 237 nucleotides downstream of the exon 3 donor splice-site in intron 3. RT-PCR confirmed the expression of only mutant transcript in all but 1 homozygote. Only very low expression of normal transcript was detected in this homozygote. (J:132697)
• Sequence Tags: Sequence tag details (1 tag)

  Tag ID	GenBank ID	Method	Tag Location (trapped strand)*	Select
  XL802	CC325326 ; (MGI Seq Detail)	5' RACE	Chr3:102096727-102104292 bp (-)
  * GRCm39; (strand of gene trap mutagenesis)

• Genome Context: Genome Browser view of this mutation;

  54 gene trap insertions have trapped this gene; View all gene trap sequence tags in this region

Disease models

Expression

In Mice Carrying this Mutation:

45 assay results 1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Vangl1 Mutation: 85 strains or lines available

Notes

All BayGenomics gene trap mutations were generated in either CGR8 or E14TG2a (129P2/OlaHsd) parental ES cell lines, with the majority in subline E14TG2a.4. The specific ES cell line in which each mutation was made is not specified.

References

• Original: J:132697 Torban E, et al., Genetic interaction between members of the Vangl family causes neural tube defects in mice. Proc Natl Acad Sci U S A. 2008 Mar 4;105(9):3449-54
• All: 13 reference(s)