Tg(Ttr-Hfe)1Nca
Transgene Detail

Summary

• Symbol: Tg(Ttr-Hfe)1Nca
• Name: transgene insertion 1, Nancy C Andrews
• MGI ID: MGI:3778909
• Synonyms: Tfr-Hfe
• Transgene: Tg(Ttr-Hfe)1Nca Location: unknown
• Alliance: Tg(Ttr-Hfe)1Nca page

Transgene origin

• Strain of Origin: C57BL/6

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Ttr-Hfe)1Nca expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Hfe (MGI:109191)

• Mutation details: The Ttr promoter was used to drive Hfe expression in a hepatocyte-specific manner. The Hfe cDNA was inserted into the second intron of Ttr. Line 1 was generated. (J:133221)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:133221 Schmidt PJ, et al., The transferrin receptor modulates Hfe-dependent regulation of hepcidin expression. Cell Metab. 2008 Mar;7(3):205-14
• All: 3 reference(s)