Ltbp1^tm1Rawe
Targeted Allele Detail

Summary

• Symbol: Ltbp1^tm1Rawe
• Name: latent transforming growth factor beta binding protein 1; targeted mutation 1, Ralf Weiskirchen
• MGI ID: MGI:3778910
• Synonyms: Ltbp1DeltaEx5^-
• Gene: Ltbp1 Location: Chr17:75312563-75699507 bp, + strand Genetic Position: Chr17, 46.24 cM, cytoband E3
• Alliance: Ltbp1^tm1Rawe page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:133255
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: A lacZ/neo cassette was inserted into exon 5. The absence of protein product was confirmed by western blot analysis on skin fibroblast extracts. This is a null allele that disrupts expression of both the long and short forms. (J:133255)

Expression

In Structures Affected by this Mutation:

8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ltbp1 Mutation: 115 strains or lines available

References

• Original: J:133255 Drews F, et al., Disruption of the latent transforming growth factor-beta binding protein-1 gene causes alteration in facial structure and influences TGF-beta bioavailability. Biochim Biophys Acta. 2008 Jan;1783(1):34-48
• All: 3 reference(s)