Stim1^tm1.1Rao
Targeted Allele Detail

Summary

• Symbol: Stim1^tm1.1Rao
• Name: stromal interaction molecule 1; targeted mutation 1.1, Anjana Rao
• MGI ID: MGI:3778912
• Gene: Stim1 Location: Chr7:101917013-102086526 bp, + strand Genetic Position: Chr7, 54.71 cM
• Alliance: Stim1^tm1.1Rao page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:133262
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Exon 2 was removed by germ-line, cre-meditated recombination. Deletion of exon 2 is predicted to result in a frameshift and creation of a premature termination site in the next exon. Authors state that this is a null allele. (J:133262)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Stim1 Mutation: 47 strains or lines available

References

• Original: J:133262 Oh-Hora M, et al., Dual functions for the endoplasmic reticulum calcium sensors STIM1 and STIM2 in T cell activation and tolerance. Nat Immunol. 2008 Apr;9(4):432-43
• All: 4 reference(s)