Gt(ROSA)26Sor^{tm1(cre/ERT2)Alj}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm1(cre/ERT2)Alj}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Alexandra L Joyner
• MGI ID: MGI:3778915
• Synonyms: Gt(ROSA)26Sor^{tm1(cre/ESR1)Alj}, Rosa26^CreERT2, Rosa26CreERT2, Rosa26^CreERT2neo
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm1(cre/ERT2)Alj} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:133568
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Gt(ROSA)26Sor^{tm1(cre/ERT2)Alj} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Gt(ROSA)26Sor (MGI:104735)

• Mutation details: A Cre/ERT2 fusion and frt flanked neo cassette were inserted into the Rosa26 locus by homologous recombination. The neo cassette was removed by Flpe mediated recombination. (J:156169)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Gt(ROSA)26Sor (mouse) Summary of all recombinase alleles driven by Gt(ROSA)26Sor. Alliance mouse Gt(ROSA)26Sor gene page

Tumor Data

List all tumor models in MMHCdb carrying Gt(ROSA)26Sor^{tm1(cre/ERT2)Alj}

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 993 strains or lines available

References

• Original: J:133568 Takeda K, et al., Essential role for prolyl hydroxylase domain protein 2 in oxygen homeostasis of the adult vascular system. Circulation. 2007 Aug 14;116(7):774-81
• All: 13 reference(s)