Ackr3^tm1.1Fma
Targeted Allele Detail

Summary

• Symbol: Ackr3^tm1.1Fma
• Name: atypical chemokine receptor 3; targeted mutation 1.1, Fabienne Mackay
• MGI ID: MGI:3778916
• Gene: Ackr3 Location: Chr1:90131702-90143446 bp, + strand Genetic Position: Chr1, 45.28 cM
• Alliance: Ackr3^tm1.1Fma page

Ackr3^tm1.1Fma/Ackr3^tm1.1Fma mice exhibit heart valve abnormalities

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:124878
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Germ-line, Cre-mediated recombination was used to remove exon 2, the coding exon. Authors state that this is a null all. (J:124878)

Expression

In Mice Carrying this Mutation:	19 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	10 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ackr3 Mutation: 34 strains or lines available

References

• Original: J:124878 Sierro F, et al., Disrupted cardiac development but normal hematopoiesis in mice deficient in the second CXCL12/SDF-1 receptor, CXCR7. Proc Natl Acad Sci U S A. 2007 Sep 11;104(37):14759-64
• All: 9 reference(s)