Grhl1^tm1Jane
Targeted Allele Detail

Summary

• Symbol: Grhl1^tm1Jane
• Name: grainyhead like transcription factor 1; targeted mutation 1, Stephen M Jane
• MGI ID: MGI:3778923
• Gene: Grhl1 Location: Chr12:24622282-24667390 bp, + strand Genetic Position: Chr12, 8.49 cM
• Alliance: Grhl1^tm1Jane page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:133318
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 1 and 2 were replaced with a lacZ and floxed neo cassette. The neo cassette was subsequently removed by germ-line, cre-mediated recombination. The absence of transcript was confirmed by RT-PCR on brain, kidney, testis, lung, stomach, liver, spleen, thymus, heart, and skin extracts. This is a null allele. (J:133318)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Grhl1 Mutation: 33 strains or lines available

References

• Original: J:133318 Wilanowski T, et al., Perturbed desmosomal cadherin expression in grainy head-like 1-null mice. EMBO J. 2008 Mar 19;27(6):886-97
• All: 6 reference(s)