Kit^W-2Btlr
Chemically induced Allele Detail

Summary

• Symbol: Kit^W-2Btlr
• Name: KIT proto-oncogene receptor tyrosine kinase; viable dominant spotting 2 Bruce Beutler
• MGI ID: MGI:3779022
• Synonyms: Kit^787F, Kit^m2Btlr, Pretty2
• Gene: Kit Location: Chr5:75735647-75817382 bp, + strand Genetic Position: Chr5, 39.55 cM
• Alliance: Kit^W-2Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: The Pretty2 mutation corresponds to an A-to-T transversion at nucleotide position 2388 of the gene (Genbank: NM_021099), in the 17th of 21 total exons, resulting in replacement of isoleucine by phenylalanine at amino acid position 787 (I787F) in the C-lobe of the protein, immediately preceding the kinase catalytic loop. (J:133613)
• Inheritance: Semidominant

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kit Mutation: 182 strains or lines available

References

• Original: J:133613 Du X, et al., Pretty2 is an allele of Kit and displays pigmentation defects. MGI Direct Data Submission. 2008
• All: 4 reference(s)