Mfn1^tm2Dcc
Targeted Allele Detail

Summary

• Symbol: Mfn1^tm2Dcc
• Name: mitofusin 1; targeted mutation 2, David C Chan
• MGI ID: MGI:3779080
• Synonyms: Mfn1^loxP
• Gene: Mfn1 Location: Chr3:32583614-32633388 bp, + strand Genetic Position: Chr3, 15.75 cM, cytoband B
• Alliance: Mfn1^tm2Dcc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:132329
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: FRT-flanked neo cassette followed by two loxP sites flanking the exon 4 encoding the canonical G-1 GTPase motif replaced the endogenous locus. The neo cassette was removed by crossing with FLP recombinase expressing mice. (J:132329)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Mfn1 Mutation: 45 strains or lines available

References

• Original: J:132329 Chen H, et al., Mitochondrial fusion protects against neurodegeneration in the cerebellum. Cell. 2007 Aug 10;130(3):548-62
• All: 45 reference(s)