Mfn2^tm3Dcc
Targeted Allele Detail

Summary

• Symbol: Mfn2^tm3Dcc
• Name: mitofusin 2; targeted mutation 3, David C Chan
• MGI ID: MGI:3779081
• Synonyms: Mfn2^loxP
• Gene: Mfn2 Location: Chr4:147958056-147989161 bp, - strand Genetic Position: Chr4, 78.56 cM
• Alliance: Mfn2^tm3Dcc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:132329
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: FRT-flanked neo cassette followed by two loxP sites flanking the exon 6 encoding the canonical G-1 GTPase motif replaced the endogenous locus. The neo cassette was removed by crossing with FLP recombinase expressing mice. (J:132329)

Disease models

Expression

In Mice Carrying this Mutation:	4 assay results 2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Mfn2 Mutation: 27 strains or lines available

References

• Original: J:132329 Chen H, et al., Mitochondrial fusion protects against neurodegeneration in the cerebellum. Cell. 2007 Aug 10;130(3):548-62
• All: 63 reference(s)