Chn1^Gt714Lex
Gene trapped Allele Detail

Summary

• Symbol: Chn1^Gt714Lex
• Name: chimerin 1; gene trap 714, Lexicon Genetics
• MGI ID: MGI:3783264
• Synonyms: alpha-2^-, alpha2^gt
• Gene: Chn1 Location: Chr2:73441004-73605690 bp, - strand Genetic Position: Chr2, 43.78 cM
• Alliance: Chn1^Gt714Lex page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:128698
• Parent Cell Line: Lex-1 (ES Cell)
• Strain of Origin: 129S5/SvEvBrd
• Project Collection: Lexicon

Mutation description

• Allele Type: Gene trapped (Hypomorph)
• Mutation: Insertion of gene trap vector
• Mutation details: A beta-geo gene trap vector was inserted upstream of the promoter region for the alpha-1 N-terminally truncated isoform in the middle of the locus. Western blot analysis confirmed the absence of protein in the spinal cord and a reduction of protein production in brain extracts of homozygotes. (J:128698)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Chn1 Mutation: 44 strains or lines available

References

• Original: J:128698 Beg AA, et al., alpha2-Chimaerin is an essential EphA4 effector in the assembly of neuronal locomotor circuits. Neuron. 2007 Sep 6;55(5):768-78
• All: 4 reference(s)