Prex2^{Gt(RRD186)Byg}
Gene trapped Allele Detail

Summary

• Symbol: Prex2^{Gt(RRD186)Byg}
• Name: phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2; gene trap RRD186, BayGenomics
• MGI ID: MGI:3783295
• Synonyms: P-Rex2^-
• Gene: Prex2 Location: Chr1:11063689-11373905 bp, + strand Genetic Position: Chr1, 2.57 cM, cytoband A3
• Alliance: Prex2^{Gt(RRD186)Byg} page

Purkinje cell dendrite morphology is altered in Prex2^{Gt(RRD186)Byg}/Prex2^{Gt(RRD186)Byg} mice

Show the 3 phenotype image(s) involving this allele.

Mutation origin

• Mutant Cell Line: RRD186
• Germline Transmission: Earliest citation of germline transmission: J:133335
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Gene trapped (Null/knockout, Reporter)
• Mutation: Insertion of gene trap vector Vector: pGT1Lxf Vector Type: gene trap
• Mutation details: The gene trap vector pGT1Lxf was inserted into the intron between exons 34 and 35. The absence of transcript expression was confirmed by in situ hybridization on brain tissue. This is a null allele. (J:133335)
• Sequence Tags: Sequence tag details (1 tag)

  Tag ID	GenBank ID	Method	Tag Location (trapped strand)*	Select
  RRD186	CC199948 ; (MGI Seq Detail)	5' RACE	Chr1:11270069-11278876 bp (+)
  * GRCm39; (strand of gene trap mutagenesis)

• Genome Context: Genome Browser view of this mutation;

  6 gene trap insertions have trapped this gene; View all gene trap sequence tags in this region

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Prex2 Mutation: 114 strains or lines available

Notes

All BayGenomics gene trap mutations were generated in either CGR8 or E14TG2a (129P2/OlaHsd) parental ES cell lines, with the majority in subline E14TG2a.4. The specific ES cell line in which each mutation was made is not specified.

References

• Original: J:133335 Donald S, et al., P-Rex2 regulates Purkinje cell dendrite morphology and motor coordination. Proc Natl Acad Sci U S A. 2008 Mar 18;105(11):4483-8
• All: 5 reference(s)