Myf6^tm2(cre)Mrc
Targeted Allele Detail

Summary

• Symbol: Myf6^tm2(cre)Mrc
• Name: myogenic factor 6; targeted mutation 2, Mario R Capecchi
• MGI ID: MGI:3783305
• Synonyms: Myf6-ICN^-, Myf6-ICNp
• Gene: Myf6 Location: Chr10:107328709-107330584 bp, - strand Genetic Position: Chr10, 55.96 cM
• Alliance: Myf6^tm2(cre)Mrc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:93444
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Hypomorph, Recombinase)
• Mutation: Insertion
• Myf6^tm2(cre)Mrc expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Myf6 (MGI:97253)

• Mutation details: An IRES-Cre and frt-flanked neo cassette were inserted in the 3' UTR to allow bicistronic expression of Myf6 and Cre. Myf6^tm1(cre)Mrc was generated from this allele. Reduced transcript expression was confirmed by semi-quantitative RT-PCR at E12.5. This allele is a hypomorph. (J:93444)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Myf6 (mouse) Summary of all recombinase alleles driven by Myf6. Comparative matrix view of recombinase activities Alliance mouse Myf6 gene page

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Tumor Data

List all tumor models in MMHCdb carrying Myf6^tm2(cre)Mrc

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Myf6 Mutation: 19 strains or lines available

References

• Original: J:93444 Keller C, et al., Alveolar rhabdomyosarcomas in conditional Pax3:Fkhr mice: cooperativity of Ink4a/ARF and Trp53 loss of function. Genes Dev. 2004 Dec 1;18(21):2614-26
• All: 7 reference(s)