Pitx3^tm2Mli
Targeted Allele Detail

Summary

• Symbol: Pitx3^tm2Mli
• Name: paired-like homeodomain transcription factor 3; targeted mutation 2, Meng Li
• MGI ID: MGI:3783311
• Gene: Pitx3 Location: Chr19:46124124-46136765 bp, - strand Genetic Position: Chr19, 38.75 cM
• Alliance: Pitx3^tm2Mli page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:133341
• Parent Cell Line: E14TG2a (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The entire coding region (exons 2 through 4) was replaced by a tau-lacZ and floxed hygro cassette. The hygro cassette was removed by transient cre expression in ES cells. This is a null allele because it lacks the coding region. (J:133341)

Expression

In Mice Carrying this Mutation:

26 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pitx3 Mutation: 22 strains or lines available

References

• Original: J:133341 Vives J, et al., A mouse model for tracking nigrostriatal dopamine neuron axon growth. Genesis. 2008 Mar;46(3):125-31
• All: 1 reference(s)