Flt3^tm1Dosm
Targeted Allele Detail

Summary

• Symbol: Flt3^tm1Dosm
• Name: FMS-like tyrosine kinase 3; targeted mutation 1, Donald Small
• MGI ID: MGI:3783339
• Synonyms: Flt^ITD
• Gene: Flt3 Location: Chr5:147267551-147337299 bp, - strand Genetic Position: Chr5, 86.88 cM, cytoband G3
• Alliance: Flt3^tm1Dosm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:133528
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Conditional ready, Constitutively active)
• Mutation: Insertion
• Mutation details: Exon 14 was replaced with an exon 14 into which the internal tandem duplication (ITD) AGGACTGATTTCAGCGAA from a patient with acute myeloid leukemia was inserted. A floxed neo cassette was placed downstream of exon 15. Removal of the neo cassette increases expression and activity of this allele. (J:133528)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Flt3 Mutation: 90 strains or lines available

References

• Original: J:133528 Li L, et al., Knock-in of an internal tandem duplication mutation into murine FLT3 confers myeloproliferative disease in a mouse model. Blood. 2008 Apr 1;111(7):3849-58
• All: 10 reference(s)